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Mattle, H. (CH), MD

Department of Neurology, University of Bern, Switzerland


Heinrich Mattle is Professor and Vice Chairman of the Department of Neurology, University of Bern, Switzerland.

Dr Mattle’s main research focus on the management and treatment of acute stroke and prevention of stroke in high-risk stroke patients. He is especially interested in the outcome of acute stroke patients without visible occlusion on early arteriography, magnetic resonance imaging of the ischaemic penumbra, anticoagulation and antiaggregation in neurological patients, clopidogrel as basic therapy in high-risk stroke patients, and blood pressure and vessel recanalization in the first hours after ischaemic stroke

Dr Mattle is the principle investigator in the International Stroke Trial Switzerland, and in the PC study – a randomised clinical trial comparing the efficacy of percutaneous closure of patent foramen ovale (PFO) with medical treatment in patients with cryptogenic embolism.

Dr. Mattle has authored and co-authored more than 120 scientific papers on cerebrovascular diseases in journals such as Neuroradiology, the Journal of Neurology, Neurosurgery and Psychiatry, Stroke, Heart, Cerebrovascular Diseases, Archives of Neurology, Lancet, and the American Journal of Neuroradiology. Further Dr Mattle is author of the book ‘Neurology’.

  • Basilar artery occlusion

  • Controversy 2:

    Acute stroke with large intracranial and extracranial occlusions: bridging is more effective than IV-thrombolysis



  • Intraarterial and combined lysis

  • Natural history and treatment of dissection